Christoph Sebastian Boerlin

I spent the second year of my master program at the State University of New York at Buffalo as part of a double-degree exchange program and there, I wrote my Master´s thesis about the polyamine metabolism in prostate cancer cells working at the Roswell Park Cancer Institute in Buffalo. During that time, I performed a range of wet lab work, including cell culture, qPCR, RNAseq, western blots, HPLC and activity assays. In addition to the wet lab work, I also used dry lab techniques to further analyze the data, like constraints based modeling.

Research Interests


I started my scientific career with a Bachelor of Science in Molecular Biotechnology at the University of Heidelberg, Germany. This bachelor gave me profound knowledge in many fields of science, ranging from molecular biology, chemistry, biophysics, and cancer biology to bioinformatics. My bachelor thesis, which I wrote at the German Cancer Research Center in Heidelberg, was based on a systems biology modeling approach with an agent-based model to investigate autophagy in mammalian cells.
I really liked the systems biology approach and therefore chose to continue on this path by pursuing a Master in Integrated Systems Biology at the University of Luxembourg. In my first year in Luxembourg, I had a combination of theoretic classes and practicals in areas ranging from a transcriptional level to proteomics and metabolomics.

Project 2Development of yeast regulatory model.

The goal of this project is to acquire extensive information on gene regulation in yeast which subsequently can then be used to build a comprehensive regulatory model. The method ChIP-exo, an improved version of of ChIP-seq, will be used to map up to 50 transcription factors involved in yeast metabolism in a number of different growth conditions. This rich dataset will enable us to increase our understanding of yeast transcriptional regulation and to analyses how different transcription factors respond to different environments.


About the Project