Project 1: Development of yeast protein synthesis model.

The objective is to expand the current genome scale metabolic model for yeast by including all reactions involved in protein synthesis and to validate if this expanded model has improved predictive capability.


Research Interests


My research interest is in the computer aided understanding and design of biological systems. I had two projects during my master training period. In my first project, a diffusion-reaction model and a kinetics model were developed to study the mechanisms of the proximity channelling. Our models provide a theoretical basis for the engineering of proximity channelling between sequentially acting enzymes.  In my second project, a machine learning assisted YeastFab (MLAF) method was developed for the yeast pathway balancing. Our results showed the great power of the machine learning based strategy in the field of metabolic engineering.

About the Project

Gang Li