Research Interests


Project 11: Engineering S. cerevisiae for Vitamin Prototrophy

The aim of this project is to engineer a S. cerevisiae strain which is able to grow on simple defined growth media without supplemented vitamins on sufficient high growth rates. Rational engineering of a prototrophic organism requires fine-tuning of the transkriptional, translational and regulatory machinery of the biosynthetic pathways involved. For further insight evolutionary approaches combined with sequencing technology are followed to identify genetic adaptations underlying a developed prototrophic phenotype.  

About the Project

Research Interests


By joining the PAcMEN training network, I got the opportunity to work at the TU Delft’s Industrial Microbiology section supervised by Prof. Jack Pronk and Dr. Jean-Marc Daran. Not only the wish to understand, reconstruct and improve micro-organisms to extend their usage in industrial processes, but also exchanging knowledge and learning for instance about scientific communication and entrepreneurship within the training network drives and excites me.

Research Interests

 

During my studies of biotechnology at the Technical University Braunschweig I participated two years in the iGEM competition and got fascinated by synthetic biology and innovative ideas provided by this discipline. Carrying out my master thesis at the Systems- and Synthetic Biology group headed by Prof. Jens Nielsen at Chalmers University of Gothenburg in Sweden, I got an insight how synthetic biology can serve as a tool for metabolic engineering. Especially this combination offers a lot of space for creativity, as engineering a biological system able to produce any conceivable compound such as biofuels or pharmaceuticals. Under supervision of Prof. Christer Larsson I worked on 2‑butanol production in Saccharomyces cerevisiae and decided to pursue a Ph.D. in this or a closely related field.


Anna Kristina Wronska

Research Interests