About the Project

However, my past work and experience as well as current and future problems worldwide led me to shift my scientific focus to bioengineering. Additionially, I wanted to dive into bioinformatics and simulation models, as demand for fast and high-throughput approaches is rising. This is why I am very happy to do my PhD at SilicoLife and be a part of the PAcMEN program.

Project 4: Development of novel genome-scale reconstruction strategies for Saccharomyces cerevisiae.

The ESR4 project targets the exploration of reconstruction strategies to build regulatory models of metabolic enzymes in Saccharomyces cerevisiae. The models aim to represent the influences of transcription factors, and their regulatory mechanisms, on metabolic genes. The regulatory influences will be integrated into a metabolic network, regulating the activity of metabolic pathways. This integrated model will serve as a simulation platform for metabolic engineering and might help to identify ways to control potential or established metabolic systems towards an objective of interest. More specifically, this model will be used in a case study for indicating the best modifications to overproduce isopentenyl diphosphate, the precursor of terpenoid production pathways in yeast..

Paul Drescher

Research Interests


I started in science with a BSc in Biotechnology at the Technical University Brandenburg, Germany, which was comprised of courses in several fields of biology, bioengineering, chemistry and physics. I followed this up with a MSc in Cell and Molecular Biology at Uppsala University, Sweden. During these degrees, I performed several internships on mouse immunology at Bristol University, UK, and production of histones and application of in situ Proximity Ligation Assay at Uppsala University, Sweden.  I spent my Bachelor and Master thesis in labs at Karolinska Institutet in Solna, Sweden. My work there was focused on neutrophil immunology and assembly of protein megastructures.Throughout these diverse projects,  I gained knowledge in cell and molecular biology, immunology and cancer biology and learned a variety of wet  lab techniques, from ELISA to immunofluorescence microscopy and flow cytometry.