Project 4: Development of novel genome-scale reconstruction strategies.
The ESR4 project targets the establishment of a model on the regulatory system of metabolic enzymes. This model aims to represent the influence of transcription factors, and their regulatory mechanisms, on metabolic pathways. This might help to simulate ways to control potential or established metabolic systems towards an objective of interest. This model will be established for the metabolism of Saccharomyces cerevisiae. This combined regulatory-metabolic model will be used as a simulation platform for metabolic engineering indicating the best modifications to overproduce a specific compound. Moreover, it will be investigated algorithms to indicate alternative reactions and pathways that could circumvent existing metabolic bottlenecks in the chosen case-study.
However, my past work and experience as well as current and future problems worldwide led me to shift my scientific focus to bioengineering. Additionially, I wanted to dive into bioinformatics and simulation models, as demand for fast and high-throughput approaches is rising. This is why I am very happy to do my PhD at SilicoLife and be a part of the PAcMEN program.
I started in science with a BSc in Biotechnology at the Technical University Brandenburg, Germany, which was comprised of courses in several fields of biology, bioengineering, chemistry and physics. I followed this up with a MSc in Cell and Molecular Biology at Uppsala University, Sweden. During these degrees, I performed several internships on mouse immunology at Bristol University, UK, and production of histones and application of in situ Proximity Ligation Assay at Uppsala University, Sweden. I spent my Bachelor and Master thesis in labs at Karolinska Institutet in Solna, Sweden. My work there was focused on neutrophil immunology and assembly of protein megastructures.Throughout these diverse projects, I gained knowledge in cell and molecular biology, immunology and cancer biology and learned a variety of wet lab techniques, from ELISA to immunofluorescence microscopy and flow cytometry.